TABLE 4.
Amino acid substitutions detected by sequencing NL4-3 HIV-1 resistant to different doses of NBD-11008 and NBD-09027
| Substitutiona | Frequency of detection after treatment with: |
Location | ||||
|---|---|---|---|---|---|---|
| NBD-11008 |
NBD-09027 |
|||||
| 53 μM | 74 μM | 127 μM | 44 μM | 55 μM | ||
| S142N | 7/14 | V1 | ||||
| V208I | 3/3 | 2/5 | 9/14 | V2 | ||
| NN301–302KI | 3/3 | 5/5 | 14/14 | 3/3 | 3/3 | V3 |
| S375Y | 2/5 (S375N) | 14/14 | CD4 binding site | |||
| S405L | 3/3 | 5/5 | 14/14 | V4 | ||
| K432Q | 3/14 | 3/3 (K432R) | 3/3 (K432R) | CD4 binding site | ||
| E560D | 3/14 | gp41 | ||||
| V782L | 3/3 | 3/3 | gp41 | |||
a
Numbering is based on the HIV HXB2 sequence in the Los Alamos HIV database (http://www.hiv.lanl.gov/).