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. 2014 Sep;58(9):5164–5180. doi: 10.1128/AAC.03245-14

FIG 11.

FIG 11

(A) MPO activity of lung tissue of mice after intranasal administration of S. pneumoniae (AMRI-SP1), followed by treatment with levofloxacin or ceftriaxone alone or in combination. MPO activity was analyzed as the index of neutrophil infiltration in the lung tissue. The rate of change in absorbance was measured spectrophotometrically at 405 nm. MPO activity was defined as the concentration of enzyme degrading 1 μmol peroxide/min at 37°C and is expressed as the change in absorbance/min · mg of tissue protein. The data are expressed as mean ± SD of the results from 4 mice per group. *, significant difference with respect to untreated infected group; $, significant difference compared to monotherapy with LVX or CRO. A P value of <0.05 was considered significant for all tests. (B) Serum C-reactive protein (CRP) concentration is expressed as mean ± SD. *, significant difference with respect to untreated infected group; $, significant difference compared to monotherapy with LVX or CRO. A P value of <0.05 was considered significant for all tests.