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Cumulative survival of group of mice (n = 21) infected by intranasal challenge with multidrug-resistant S. pneumoniae isolate AMRI-SP1 and treated with antibiotics levofloxacin (LVX) and ceftriaxone (CRO) either alone or in combination, as well as the untreated control. As of 18 h postinfection (p.i.), the mice received 4 i.v. administrations of LVX at 150 mg/kg and/or CRO at 50 mg/kg of body weight with a 6-h interval between successive doses.
