FIG 6.

Serum levels of IL-6 (a), IL-10 (b), TNF-α (c), and IFN-γ (d) in different groups of mice at 0 to 24 h after antibiotic treatment. The levels of IL-6 (a), IL-10 (b), TNF-α (c), and IFN-γ (d) in serum from S. pneumoniae-infected mice untreated or treated with levofloxacin (LVX) at 150 mg/kg and/or ceftriaxone (CRO) at 50 mg/kg 18 h postinfection were determined by utilizing ELISA, according to the manufacturer's instruction, and the values obtained are expressed in pg/ml as mean ± SD (n = 3/group). AMRI-SP1-infected animals that were left untreated were considered a control for comparison with those treated with LVX or CRO or both. *, significant difference with respect to infected control group; $, significant difference compared to monotherapy with LVX or CRO. A P value of <0.05 was considered to be significant for all tests.