TABLE 3.

Patients with defective IFN-γ production upon PBMC stimulation

Age (yr)	Sexa	Group	Clinical pictureb	Stimulic,d	Diagnosis-test intervald	Lymphocyte count/mm3d	Underlying defecte
46	F	NIIDf	Idiopathic erythema nodosum	1	2 yr	1,790	NP
36	M	NIID	Hidradenitis	1	Continuously	2,690	NP
59	F	NIID	Hidradenitis, pyoderma gangrenosum, ankylosing spondylitis	2/2	Continuously	1,030/510	NP
50	F	NIID	Sterile subareolar abscesses	2	19 mo	3,040	NP
26	F	NIID	Episodic fever, abdominal pain, arthralgia	1	17 mo	1,880	NP
18	F	NIID	EBV-driven cutaneous T-cell lymphoma of childhood	1	9 mo	950	232-kb loss in chromosome 16p11.2
48	M	Infection	Progressive multifocal leukoencephalopathy	2	5 mo	NAg	NP
51	M	Infection	Intraocular varicella-zoster virus infection	1	2 mo	1,990	NP
49	F	Infection	Recurrent varicella-zoster virus infection	2/2	1 mo/NA	1,680/2,660	NP
61	M	Infection	Recurrent bacterial skin infection	1	3 wk/10 mo	1,220/NA	NP
35	F	Infection	Recurrent impetigo, RVVC	1/1/1/1	4 mo/6 mo/12 mo/14 mo	1,820/2,300/2,890/1,820	NP
56	F	Infection	Disseminated M. avium infection, Legionella dumoffii pneumonia	1/1	1 mo/2 yr	1,860/1,810	NP
68	F	Infection	M. avium and Mycobacterium intracellulare pneumonia	1	4 mo	1,680	NP
54	M	Infection	Mycobacterium chelonae skin infection	1	9 mo	2,080	NP
67	M	Infection	M. abscessus pneumonia, ABPA	1/1	2 mo/2 mo	810/800	NP
67	M	Infection	M. intracellulare pneumonia	2	3 yr 8 mo	1,700	NP
34	V	Infection	Oral and vaginal candidiasis, furunculosis	1	1 wk	3,140	NP
20	F	Infection	Chronic mucocutaneous candidiasis	2	Continuously	NA	NP
48	F	Infection	Persistent oropharyngeal candidiasis, onychomycosis, asplenia, vitiligo	1	Continuously	1,200	APECED
28	F	Infection	RVVC, impetigo, hidradenitis, granulomatous intestinal inflammation	1	Continuously	1,500	HIES
36	F	Infection	Chronic mucocutaneous candidiasis	2	Continuously	900	STAT1 mutation
42	F	Infection	RVVC	1	NA	1,180	NP
30	F	Infection	Recurrent oropharyngeal candidiasis	1	2 mo	1,940	NP
49	M	Infection	Disseminated aspergillosis, pulmonary nocardiosis and R. equi infection, Alternaria skin infection	1	3 yr	990	CD4 lymphopenia
57	M	Infection	Skin abscesses, recurrent pneumonia, eczema	1	2 mo	2,300	HIES
63	F	Infection	Aspergillus skull base osteomyelitis	1	3 yr	NA	NP
66	F	Infection	Recurrent Candida esophagitis, onychomycosis, hypothyroidism	1	Continuously	900	CMC, STAT1 negative

^aF, female; M, male.

^bEBV, Epstein-Barr virus; RVVC, recurrent vulvovaginal candidiasis; ABPA, allergic bronchopulmonary aspergillosis.

^cNumber of stimuli that resulted in a deficient response.

^dData from patients tested more than once are shown separated by a slash in the same column.

^eNP, not performed; APECED, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy; HIES, hyper-IgE syndrome; STAT, signal transducer and activator of transcription; CMC, chronic mucocutaneous candidiasis.

^fNIID, noninfectious inflammatory disorder.

^gNA, not available.