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. 2014 Aug;88(15):8579–8596. doi: 10.1128/JVI.00666-14

TABLE 2.

Virulence scores from the six different assays with parental rBC and rGBT and their chimeric viruses

Swap Virulence scorea
In vitro replication Plaque size Fusion index ICPI In vivo replication Clinical signs/mortality
rBC derivatives, rGBT envelope-associated protein genes
    M Ø Ø Ø Ø Ø -
    F +++ +++ +++ +++ +++ +++
    HN Ø + + + Ø -
    F+HN +++ ++ +++ +++ +++ +++
    M+F+HN ++ ++++ ++++ +++ ++ ++
rGBT derivatives, rBC envelope-associated protein genes
    M Ø --- Ø - Ø Ø
    F --- - --- --- --- ---
    HN Ø ++ Ø Ø Ø Ø
    F+HN --- --- --- -- -- ---
    M+F+HN --- --- ---- -- --- -
rBC derivatives, rGBT polymerase-associated protein genes
    N Ø --- ND Ø Ø -
    P Ø -- ND Ø Ø -
    L + -- ND ++ ++ +++
    N+P+L ++ +++ ND ++ +++ ++
    Tr Ø Ø ND Ø Ø Ø
rGBT derivatives, rBC polymerase-associated protein genes
    N - - ND Ø Ø Ø
    P - Ø ND Ø Ø Ø
    L -- --- ND -- -- --
    N+P+L --- ---- ND -- --- ---
    Tr -- Ø ND Ø Ø Ø
a

Increases and decreases in virulence relative to the respective parent are indicated as + and - symbols, respectively. The scoring is for a descriptive comparison and was not intended to be quantitative. ND, not determined; Ø, no observable effect.