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Types of neuropathologic lesions in the brains of subtype B R5 SHIVSF162P3N-infected macaques. Shown are SIV+ cells as revealed by in situ hybridization in cortical perivascular histolytic lesions with MNGCs (1), thalamic expansive lesions with white matter damage (2), and vacuolated chronic burnt-out lesions (3). Subsets of CD163+, Mac387+, and CD68+ macrophages are demonstrated by IHC in the insets, with SIV (green), CD68 (red), and glut-1 (blue) shown in the confocal inset.
