FIG 5.

Phylogenetic tree analysis of env sequences in the blood and brains of subtype C SHIVE macaques. Neighbor-joining phylogenetic trees of env V3-to-V5 sequences from the plasma, CSF, cerebellum, and occipital and parietal regions of the brains of SHIVC-infected macaques GC98 and FI08 rooted to ZM109F.PB4 are shown, with bootstrap values of >70% indicated at the appropriate nodes. Genetic distances representing the number of nucleotide substitutions per site between env sequences (0.005) are indicated at the bottom of each tree. *, sequence obtained by SGA.