TABLE 1.
Characteristics of subtype B R5 SHIVSF162P3N-, subtype C SHIVC109P3-, and SHIVC109P3N-infected macaques with SHIVEa
| Virus | Animal | Age (yr) |
Mamu alleleb |
Route | Dose (TCID50)c | Time to AIDS (wk) | Coreceptor switch (X4 V3 sequence)e | SHIV binding antibody | ||
|---|---|---|---|---|---|---|---|---|---|---|
| A*01 | B*08 | B*17 | ||||||||
| SHIVSF162P3N | DE86 | 5.69 | − | − | − | I.v. | 3,000 | 12d | Yes (GHI insertion) | Transient |
| T799 | 9.90 | − | − | − | I.v. | 3,000 | 224 | Yes (S11 K/R) | High, persistent | |
| DG07 | 6.71 | − | − | − | I.r. | 10,000 | 7d | No | Transient | |
| DG08 | 6.98 | − | − | − | I.r. | 10,000 | 20d | Yes (HI/HR insertion, ΔATGD) | Not detected | |
| DN57 | 5.84 | − | − | − | I.r. | 10,000 | 30d | No | Weak, persistent | |
| ET94 | 6.50 | − | − | − | I.r. | 10,000 | 39 | Yes (HR insertion) | Weak, persistent | |
| DG17 | 8.55 | − | − | − | I.vg. | 1,000 | 22d | No | Not detected | |
| SHIVC109P3 | GC98 | 7.21 | + | − | − | I.r. | 5,000 | 20d | No | Not detected |
| SHIVC109P3N | FI08 | 7.62 | − | − | − | I.r. | 5,000 | 10d | Yes (ΔIGDI) | Not detected |
a
The age at the time of virus challenge, status of restrictive MHC class I genotype, inoculation route, dose of the virus inoculum and time to AIDS of the SHIVE macaques are shown. Presence of coreceptor switch, V3 sequence dictating the switch to CXCR4 usage, and status of SHIV binding antibody in the animals are also indicated.
b
−, absent; +, present.
c
TCID50, 50% tissue culture infectious dose.
d
Rapid progressor.
e
Δ denotes deletion in the V3 loop.