TABLE 2.
Temporal pattern of PrPSc deposition and synaptophysin colocalization in muscle cells of the tongue
| Time postinfection and animala | No. of PrPSc-positive muscle cells | PrPSc deposition profile (no. of cells [%])b |
||
|---|---|---|---|---|
| PrPSc-positive muscle cells in a focal patternc | PrPSc and synaptophysin colocalization in muscle cells | PrPSc and synaptophysin colocalization in a focal pattern | ||
| Week 7 | ||||
| Animal 3 | ||||
| Ipsilaterald | 216 | 126 (58) | 117 (54) | 112 (96) |
| Contralaterald | 28 | 24 (86) | 23 (82) | 23 (100) |
| Week 9 | ||||
| Animal 1 | 101 | 47 (47) | 31 (31) | 27 (82) |
| Animal 2 | 100 | 60 (60) | 47 (47) | 46 (98) |
| Animal 3 | 100 | 90 (90) | 89 (89) | 83 (93) |
| Week 13 | ||||
| Animal 1 | 133 | 2 (2) | 3 (2) | 1 (33) |
| Animal 2 | 152 | 6 (4) | 5 (3) | 4 (80) |
| Animal 3 | 261 | 18 (7) | 26 (10) | 17 (65) |
a
Animal numbering corresponds to Fig. 3.
b
The percentage is calculated in terms of the counted PrPSc-positive cells except for percentages in the last column, which are percentages of the number of cells in the previous column.
c
Focal PrPSc pattern deposition is described in the legend of Fig. 4B.
d
Ipsilateral and contralateral to the site of inoculation in the hypoglossal nerve. Data for week 9 and 13 tongue are from an area ipsilateral to the site of inoculation.