FIG 1.

Effects of epinecidin-1 (epi) treatment on mice infected with P. aeruginosa R or P. aeruginosa ATCC 19660. (A and B) Mice were injected with P. aeruginosa ATCC 19660 (A) or P. aeruginosa R (B), and independent groups (n = 27) were subsequently injected with epinecidin-1, clarithromycin, or imipenem. The survival rate was monitored on a daily basis for up to 7 days. (C and D) To determine the curative potential, mice were first injected with P. aeruginosa ATCC 19660 (C) or P. aeruginosa R (D) and then with epinecidin-1 (0.005 mg/g) 10, 60, 120, 180, or 360 min later. At these injection times, the P. aeruginosa ATCC 19660 experimental groups exhibited survival rates of 93.3%, 73.3%, 60.0%, 46.6%, and 33.3%, respectively, while the P. aeruginosa R experimental groups exhibited survival rates of 93.3%, 60.0%, 60.0%, 46.6%, and 20.0%, respectively.