TABLE 1.
Effect of epinecidin-1, clarithromycin, and imipenem on mouse survival following intraperitoneal injection of 107 CFU of P. aeruginosa ATCC 19660 or P. aeruginosa Ra
| Strain and treatment | % lethality | Mean ± SD bacterial count (CFU/ml) in: |
||||
|---|---|---|---|---|---|---|
| Blood | Peritoneum | Spleen | Liver | Mesenteric lymph nodes | ||
| P. aeruginosa ATCC 19660 | ||||||
| No treatment | 93.34C | 8.9 × 106 ± 2.4 × 106B | 2.6 × 109 ± 1.0 × 109B | 2.8 × 109 ± 1.6 × 109B | 3.3 × 109 ± 1.0 × 109B | 4.3 × 109 ± 2.1 × 109B |
| Clarithromycin (0.01 mg/g) | 95.34D | 8.9 × 106 ± 1.0 × 106B | 3.4 × 109 ± 1.4 × 109B | 2.6 × 109 ± 1.2 × 109B | 3.6 × 109 ± 2.0 × 109B | 4.3 × 109 ± 1.0 × 109B |
| Imipenem (0.01 mg/g) | 0A | 0A | 1.7 × 106 ± 1.0 × 106A | 2.2 × 106 ± 0.6 × 106A | 2.8 × 106 ± 1.0 × 106A | 1.8 × 106 ± 1.0 × 106A |
| Epinecidin-1 (5 μg/g) | 5B | 0A | 3.1 × 106 ± 1.2 × 106A | 1.3 × 106 ± 1.0 × 106A | 3.8 × 106 ± 1.4 × 106A | 1.3 × 106 ± 1.6 × 106A |
| P. aeruginosa R | ||||||
| No treatment | 88.6C | 7.9 × 106 ± 1.4 × 106B | 4.6 × 109 ± 1.6 × 109C | 2.8 × 109 ± 1.6 × 109C | 3.3 × 109 ± 1.0 × 109B | 4.3 × 109 ± 2.1 × 109B |
| Clarithromycin (0.01 mg/g) | 88.6C | 8.4 × 106 ± 1.0 × 106B | 2.4 × 109 ± 1.4 × 109C | 2.6 × 109 ± 1.2 × 109C | 3.6 × 109 ± 2.0 × 109B | 4.3 × 109 ± 1.0 × 109B |
| Imipenem (0.01 mg/g) | 60.97B | 1.7 × 106 ± 1.0 × 106B | 4.7 × 107 ± 1.0 × 107B | 1.2 × 107 ± 0.2 × 107B | 3.6 × 109 ± 2.0 × 109B | 1.7 × 106 ± 1.0 × 106A |
| Epinecidin-1 (5 μg/g) | 0A | 0A | 4.1 × 105 ± 1.0 × 105A | 5.3 × 106 ± 1.8 × 106A | 3.5 × 107 ± 1.4 × 107A | 2.4 ×06 ± 1.0 × 106A |
a
Lethality was monitored for 48 h following the injection of epinecidin-1 or antibiotics. Different letters indicate a significant difference between two groups.