TABLE 3.

Genes up- and downregulated by epinecidin-1 in mice, as determined by microarray analysis

GO no.	Function	Count (no. of genes)	P value
GO:0007166	Cell surface receptor-linked signal transduction	200	0.03687171
GO:0007186	G-protein-coupled receptor protein signaling pathway	159	0.01237965
GO:0016071	mRNA metabolic process	30	0.06115789
GO:0034621	Cellular macromolecular complex subunit organization	28	0.01568345
GO:0034622	Cellular macromolecular complex assembly	27	0.00627889
GO:0006461	Protein complex assembly	26	0.01967148
GO:0070271	Protein complex biogenesis	26	0.01967148
GO:0032940	Secretion by cell	24	0.00674446
GO:0046903	Secretion	24	0.04300132
GO:0008380	RNA splicing	21	0.08089444
GO:0006457	Protein folding	16	0.03637995
GO:0010817	Regulation of hormone levels	16	0.03861235
GO:0016042	Lipid catabolic process	15	0.0956397
GO:0007018	Microtubule-based movement	14	0.02684929
GO:0003001	Generation of a signal involved in cell-cell signaling	13	0.01552742
GO:0006887	Exocytosis	13	0.0916722
GO:0033365	Protein localization in organelle	12	0.08372683
GO:0046942	Carboxylic acid transport	12	0.09359128
GO:0015931	Nucleobase, nucleoside, nucleotide, and nucleic acid transport	11	0.03636812
GO:0034504	Protein localization in nucleus	10	0.0278588
GO:0032269	Negative regulation of cellular protein metabolic process	10	0.06888556
GO:0006022	Aminoglycan metabolic process	8	0.0742951
GO:0006953	Acute-phase response	7	0.01744936
GO:0046879	Hormone secretion	7	0.06848175
GO:0009914	Hormone transport	7	0.07531571
GO:0030072	Peptide hormone secretion	6	0.09087306
GO:0006970	Response to osmotic stress	5	0.02885352
GO:0010741	Negative regulation of protein kinase cascade	5	0.09817185
GO:0030433	Endoplasmic reticulum-associated protein catabolic process	4	0.06021506