TABLE 1.
Antiviral activity of samatasvir against 17 RNA and DNA virusesa
| Genome type and virus family | Virus (strain) | Cell line | EC50 (μM) |
|---|---|---|---|
| RNA | |||
| Flaviviridae | Bovine viral diarrhea virus (NADL) | MDBK | 33.4 |
| Dengue virus, serotype 2 (New Guinea C) | Huh-7 | >50 | |
| West Nile virus (NY-99) | Vero | >50 | |
| Yellow fever virus (17D) | HeLa | 16.5 | |
| Orthomyxoviridae | Influenza A virus (A/Victoria/3/75 [H3N2]) | MDCK | >50 |
| Influenza B virus (Lee) | MDCK | >50 | |
| Paramyxoviridae | Measles virus (Edmonston) | HeLa | >50 |
| Respiratory syncytial virus (Long) | Vero | >50 | |
| Picornaviridae | Coxsackie B virus (B4) | Vero | >50 |
| Poliovirus (Chat) | Vero | >50 | |
| Rhinovirus (1B) | MRC-5 | >50 | |
| Retroviridae | Human immunodeficiency virus type 1 (Ba-L) | MAGI-CCR5 | >50 |
| Togaviridae | Venezuelan equine encephalitis virus (Trinidad) | Vero E6 | >50 |
| Reoviridae | Rotavirus (WI61) | Vero | >50 |
| DNA | |||
| Herpesviridae | Herpes simplex virus 1 (HF) | Vero | >50 |
| Poxviridae | Monkeypox virus (Zaire) | Vero E6 | >50 |
| Vaccinia virus (WR-56) | Vero E6 | >50 |
a
The values are from a single data set. The samatasvir CC50 values for each cell line used were >50 μM.