TABLE 12.
Activity of samatasvir against genotype 1b and 2a replicons bearing amino acid substitutions in NS5A
| Substitution | Genotype | Mean fold change ± SDa |
Replicative capacity (% of WT ± SD)a | ||
|---|---|---|---|---|---|
| Samatasvir | Daclatasvir | IDX184 | |||
| L28T | 1b | 74 ± 7 | 25 ± 4 | 0.51 ± 0.01 | 3 ± 1 |
| R30E | 1b | 1.1 ± 0.0 | 7.3 ± 0.7 | 0.52 ± 0.07 | 17 ± 5 |
| L31F | 1b | 4.0 ± 0.4 | 6.9 ± 1.8 | 0.88 ± 0.09 | 90 ± 15 |
| L31M | 1b | 3.6 ± 0.6 | 3.2 ± 0.8 | 0.91 ± 0.20 | 86 ± 7 |
| L31M | 2a | 90 ± 16 | NDb | ND | 69 ± 19 |
| L31V | 1b | 15 ± 2 | 23 ± 7 | 0.92 ± 0.22 | 61 ± 10 |
| P32L | 1b | 6.7 ± 3.7 | 9.6 ± 1.0 | 0.66 ± 0.14 | 12 ± 6 |
| Y93C | 1b | 2.7 ± 0.3 | 2.1 ± 0.1 | 0.73 ± 0.14 | 33 ± 8 |
| Y93H | 1b | 93 ± 22 | 21 ± 3 | 0.75 ± 0.14 | 25 ± 5 |
| Y93N | 1b | 160 ± 30 | 35 ± 5 | 0.69 ± 0.14 | 23 ± 6 |
a
n = 3.
b
ND, not done.