TABLE 3.
Cytotoxicity profile of samatasvir in human cell lines
| Cell line | Tissue | Mean CC50 ± SD (μM) of: |
|
|---|---|---|---|
| Samatasvir | Daclatasvir | ||
| Zluca,d | Liver | >100 | 19 ± 4 |
| HepaRGb,d,g | Liver | >100 | 23.7 ± 1.2 |
| CAKI-1c,e | Kidney | >50 | 25.5 ± 2.1 |
| CCRF-CEMc,e | Blood | >50 | 10.5 ± 2.1 |
| COLO-205c,e | Intestine | >50 | 17.0 ± 1.4 |
| SJCRH30c,e | Skeletal muscle | >50 | 14.5 ± 0.7 |
| SNB-78c,f | CNSh | >50 | 15.0 |
a
Three-day assay using CellTiter-Blue.
b
Fourteen-day assay using WST-1.
c
Three-day assay using X CellTiter-Glo.
d
n = 3.
e
n = 2.
f
n = 1.
g
Diclofenac (positive control) had a characteristic CC50 (mean ± SD) of 175.8 ± 14.2 μM.
h
CNS, central nervous system.