TABLE 5.
Samatasvir used in combination with other drug classes in the replicon
| Compound added to samatasvir | No. of independent expts | Drug classa | Combination model |
||
|---|---|---|---|---|---|
| Bliss independence | Loewe additivity | Combination index | |||
| Interferon alfa | 7 | Additive | Additive | Mild synergy | |
| Ribavirin | 7 | Additive-to-weak antagonism | Additive | Mild antagonism | |
| IDX184 | 7 | NI | Additive | Additive | Additive |
| TMC647055 | 8 | NNI | Additive | Additive | Additive |
| Telaprevir | 6 | PI | Additive | Additive | Moderate antagonism |
| Boceprevir | 6 | PI | Additive | Additive | Moderate antagonism |
| Simeprevir | 8 | PI | Additive | Additive | Additive |
a
NI, nucleoside inhibitor; NNI, nonnucleoside inhibitor; PI; protease inhibitor.