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In vitro cytotoxicity in HepG2 cells after 3 days of treatment
| Compound | Mean CC50 ± SD (μM) fora: |
|||
|---|---|---|---|---|
| LDHe | Glucose | XTT | PAC | |
| Samatasvir | >100 | >100 | >100 | >100 |
| Daclatasvir | 17.4 ± 0.3 | 14.9 ± 3.7 | 17.7 ± 3.1 | 17.6 ± 1.6 |
| Doxorubicin | 0.26 | 0.06 ± 0.02 | 0.46 ± 0.04 | 0.06 ± 0.01 |
n = 3. Cytotoxicity endpoints were membrane permeability for LDH3, physiological cell state for glucose, mitochondrial metabolism for XTT, and lysosomal activity for PAC.
