TABLE 9.

Amino acid substitutions identified by population sequencing of untreated or samatasvir-selected genotype 1a replicon cells^a

Region	Substitution	719R-A	Untreated control A	719R-B	Untreated control B	719R-C	Untreated control C
NS3	T260A	Dominant	Minor	Minor		Dominant
	D518N	Dominant	Dominant	Minor	Minor	Dominant	Minor
	H593R	Minor			Minor
NS4B	E15G	Dominant	Minor	Dominant	Minor	Dominant	Minor
NS5A	Y93H	Dominant		Dominant		Dominant
	E295G	Dominant	Minor			Dominant
	R318W	Minor		Minor		Dominant
	C404W	Minor	Minor		Minor
	Y413H					Minor
	L419P					Minor
	E420K	Minor
NS5B	F574S			Minor

^aThe 719R-A/untreated control A, 719R-B/untreated control B, and 719R-C/untreated control C cell lines represent three independent experiments.