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. 2014 Aug;58(8):4328–4340. doi: 10.1128/AAC.02825-14

FIG 2.

FIG 2

Mapping of amino acid changes and frameshift mutations in the herpesvirus TK selected under pressure of KAY-2-41 and KAH-39-149. Shown is a schematic representation of the TK of HSV-1, MHV-68, and HVS. The ATP-binding site, the nucleoside-binding site, and the regions conserved among herpesvirus TKs are indicated by black boxes. Amino acid changes and frameshift mutations in the herpesvirus TK that have not previously been reported in vitro or in patients are underlined. nts, nucleotides.