TABLE 4.

Plasma binding studies^a

Test compound and concn (μg/ml)	Mean % bound to plasma ± SD
	Human	Dog	Rat
Amixicile
1	95.9 ± 0.437	84.3 ± 0.473	89.4 ± 0.945
10	94.5 ± 0.440	86.8 ± 0.208	87.5 ± 0.529
100	92.1 ± 0.640	79.0 ± 1.30	80.0 ± 0.954
VPC16a1011
1	100	101	100
10	99.4	98.4 ± 0.577	99.2
50	99.8	98.8 ± 0.577	99.8 ± 0.058

^aStudies employed equilibrium dialysis. VPC16a1011 is a hydrophobic analogue of amixicile.