TABLE 5.

PK data from rat single-dose experiments^a

Amixicile dose (mg/kg) and rat no. or parameter	Cmax (μg/ml)	Tmax (h)	AUClast (h · μg/ml)	AUCinf (h · μg/ml)	t1/2 (h)	V/F (liters/kg)	CL/F (ml/h/kg)
30
15	20.4	0.50	107	107	1.54	0.621	279
16	14.8	0.50	70.6	70.6	1.65	1.01	425
17	11.2	1.00	59.6	59.8	1.39	1.00	501
Mean ± SD	15.5 ± 4.6	0.67 ± 0.29	79.2 ± 25.0	79.3 ± 24.9	1.53 ± 0.13	0.879 ± 0.224	402 ± 113
100
18	18.7	8.0	298	331	6.50	2.84	303
19	21.8	1.00	323	323	2.04	0.91	309
20	18.6	0.50	283	330	8.25	3.62	303
Mean ± SD	19.7 ± 1.8	3.17 ± 4.19	301 ± 20	328 ± 4	5.60 ± 3.22	2.45 ± 1.39	305 ± 4

^aSingle doses of amixicile (30 and 100 mg/kg) were administered to male rats. The results for individual rats are depicted with the means and SDs.