FIG 3.

Weight loss or gain for animals infected with Trypanosoma cruzi Y strain and treated with fexinidazole sulfoxide or fexinidazole sulfone. Infected mice were treated once daily with 10, 25, 50, or 100 mg/kg of fexinidazole sulfoxide, fexinidazole sulfone, or benznidazole for 20 consecutive days, and results were compared with those for infected and untreated control (IC) and noninfected control (NIC) groups. The weight loss or gain was calculated as the difference between the weights of animals before and after treatment. The weights of animals in the uninfected control group were assessed over the same period. The weights of the animals in the infected and untreated control group were assessed 14 days after infection (all animals died before the end of the treatment). a, significant difference relative to infected control (P < 0.005); b, significant difference relative to uninfected control (P < 0.005).