FIG 4.

Parasitemia levels during and after oral administration of fexinidazole sulfoxide or fexinidazole sulfone. Bars represent the means of the maximum parasitemia values obtained in peripheral blood samples from mice (n = 10) infected with 5,000 trypomastigotes of Trypanosoma cruzi Y strain during and up to 30 days after 20 days of treatment with doses of 10, 25, 50, or 100 mg/kg/day of fexinidazole sulfoxide, fexinidazole sulfone, or benznidazole. IC, infected and untreated control. a, b, and c, bars with similar letters are not significantly different, and bars with different letters are significantly different (P < 0.05).