TABLE 2.

Pharmacokinetic parameters for fexinidazole, fexinidazole sulfoxide, and fexinidazole sulfone after single oral administration of fexinidazole sulfoxide or fexinidazole sulfone to uninfected mice

Drug administered and dose (mg/kg)	Parameter	Fexinidazole	Fexinidazole sulfoxide	Fexinidazole sulfone
Fexinidazole sulfoxide
10	Cmax (μg/ml)	0.012	3.56	6.88
	Tmax (h)	0.5	0.5	2.0
	AUCinf (μg·h/ml)	CNCa	7.68	43.4
	Half-life (h)	CNC	0.8	1.9
25	Cmax (μg/ml)	0.053	13.1	14.8
	Tmax (h)	0.5	0.5	2.0
	AUCinf (μg·h/ml)	0.070	27.1	117
	Half-life (h)	0.80	0.7	2.1
50	Cmax (μg/ml)	0.130	21.6	35.4
	Tmax (h)	0.5	0.5	2.0
	AUCinf (μg·h/ml)	0.180	54.4	308
	Half-life (h)	1.8	1.3	2.0
100	Cmax (μg/ml)	0.330	32.9	58.4
	Tmax (h)	0.25	0.5	4.0
	AUCinf (μg·h/ml)	0.480	160	806
	Half-life (h)	2.6	1.5	2.2
Fexinidazole sulfone
10	Cmax (μg/ml)	ND	ND	8.48
	Tmax (h)			1.0
	AUCinf (μg·h/ml)			46.6
	Half-life (h)			2.0
25	Cmax (μg/ml)	ND	ND	21.0
	Tmax (h)			1.0
	AUCinf (μg·h/ml)			124
	Half-life (h)			3.2
50	Cmax (μg/ml)	ND	ND	33.5
	Tmax (h)			2.0
	AUCinf (μg·h/ml)			304
	Half-life (h)			2.3
100	Cmax (μg/ml)	ND	ND	67.6
	Tmax (h)			2.0
	AUCinf (μg·h/ml)			624
	Half-life (h)			2.2

^aCNC, could not calculate; ND, not detected.