TABLE 6.
Birth defect rates and adjusted odds ratios by onset of fluoroquinolone exposure
| Gestational wk at onset of therapy | No. of pregnancies | No. of live-born infants | No. of birth defects/total no. (%) | ORadj (95% CI)a | No. of major birth defects/total no. (%) | ORadj (95% CI) |
|---|---|---|---|---|---|---|
| 2 | 229 | 182 | 11/184b (6.0) | 0.92 (0.5–1.7) | 2/182b (1.1) | 0.40 (0.1–1.6) |
| 3 | 225 | 187 | 13/188b (6.9) | 1.09 (0.6–2.0) | 6/188b (3.2) | 1.20 (0.5–2.8) |
| 4 | 192 | 149 | 7/151b (4.6) | 0.70 (0.3–1.5) | 3/149b (2.0) | 0.74 (0.2–2.4) |
| 5 | 135 | 113 | 4/114b (3.5) | 0.54 (0.2–1.5) | 3/114b (2.6) | 0.98 (0.3–3.2) |
| 6 | 66 | 59 | 3/60b (5.0) | 0.78 (0.2–2.5) | 2/60b (3.3) | 1.26 (0.3–5.3) |
| 7 | 40 | 36 | 4/37b (10.8) | 1.81 (0.6–5.2) | 2/37b (5.4) | 2.10 (0.5–8.9) |
| 8–12 | 43 | 36 | 1/36b (2.8) | 0.44 (0.1–3.3) |
a
ORadj, adjusted odds ratio; CI, confidence interval.
b
Various denominators are due to various numbers of elective terminations of pregnancy/spontaneous abortions with major, minor, or genetic birth defects considered in numerators and denominators.