TABLE 2.
Minimal inhibitory concentration and minimal biofilm inhibition concentration of antibiotics alone or in combination with d-amino acids
| Antimicrobial agenta | Class | Planktonic MICb (μg/ml) for: |
Biofilm MBICb (μg/ml) for: |
||
|---|---|---|---|---|---|
| S. aureus UAMS-1 | S. aureus SAMMC-700 | S. aureus UAMS-1 | S. aureus SAMMC-700 | ||
| CLI | Lincosamide | 0.5 | 0.5 | 256 | 512 |
| CLI + d-AA | 0.25 | 0.5 | 32 | 128 | |
| CFZ | Cephem | 0.5 | 16 | 512 | 1,024 |
| CFZ + d-AA | 0.5 | 16 | 512 | 1,024 | |
| OXA | Penicillin | 1 | 8 | 256 | >1,024 |
| OXA + d-AA | 1 | 8 | 256 | >1,024 | |
| RIF | Ansamycin | 0.5 | 0.5 | 32 | 64 |
| RIF + d-AA | 0.5 | 0.5 | 8 | 8 | |
| VAN | Glycopeptide | 0.5 | 1 | 256 | 512 |
| VAN + d-AA | 0.5 | 1 | 128 | 128 | |
a
CLI, clindamycin; CFZ, cefazolin; OXA, oxacillin; RIF, rifampin; VAN, vancomycin.
b
MIC and minimum biofilm inhibition concentration (MBIC) of the antibiotic (μg/ml) alone or in combination with an equimolar mixture of d-Phe/d-Trp/d-Met (5 mM).