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. 2014 Aug;58(8):4353–4361. doi: 10.1128/AAC.02468-14

TABLE 3.

MIC and minimal biofilm inhibition concentration of antibiotics alone or in combination with d-amino acids

Antimicrobial agenta Class Planktonic MICb (μg/ml) for:
Biofilm MBICb (μg/ml) for:
SAMMC-189 SAMMC-418 SAMMC-189 SAMMC-418
AMK Aminoglycoside 16 16 512 >1,024
AMK + d-AA 8 16 512 >1,024
CS Lipopeptide 1 1 256 256
CS + d-AA 1 1 32 64
CIP Fluoroquinolone 4 8 128 256
CIP + d-AA 4 8 32 32
IMI Carbapenem 128 64 256 256
IMI + d-AA 128 64 256 128
TAZ Cephem 16 2 512 >1,024
TAZ + d-AA 8 2 512 512
a

AMK, amikacin; CS, colistin; CIP, ciprofloxacin; IMI, imipenem; TAZ, ceftazidime.

b

MIC and minimum biofilm inhibition concentration (MBIC) of the antibiotic (μg/ml) alone or in combination with an equimolar mixture of d-Phe/d-Trp/d-Met (5 mM).