TABLE 3.
MIC and minimal biofilm inhibition concentration of antibiotics alone or in combination with d-amino acids
| Antimicrobial agenta | Class | Planktonic MICb (μg/ml) for: |
Biofilm MBICb (μg/ml) for: |
||
|---|---|---|---|---|---|
| SAMMC-189 | SAMMC-418 | SAMMC-189 | SAMMC-418 | ||
| AMK | Aminoglycoside | 16 | 16 | 512 | >1,024 |
| AMK + d-AA | 8 | 16 | 512 | >1,024 | |
| CS | Lipopeptide | 1 | 1 | 256 | 256 |
| CS + d-AA | 1 | 1 | 32 | 64 | |
| CIP | Fluoroquinolone | 4 | 8 | 128 | 256 |
| CIP + d-AA | 4 | 8 | 32 | 32 | |
| IMI | Carbapenem | 128 | 64 | 256 | 256 |
| IMI + d-AA | 128 | 64 | 256 | 128 | |
| TAZ | Cephem | 16 | 2 | 512 | >1,024 |
| TAZ + d-AA | 8 | 2 | 512 | 512 | |
AMK, amikacin; CS, colistin; CIP, ciprofloxacin; IMI, imipenem; TAZ, ceftazidime.
MIC and minimum biofilm inhibition concentration (MBIC) of the antibiotic (μg/ml) alone or in combination with an equimolar mixture of d-Phe/d-Trp/d-Met (5 mM).