TABLE 3.

Kinetic parameters with avibactam

Parameter	β-Lactamase
	CMY-2	P99	PDC-1
Ki app (µM) avibactam	26 ± 3	Not available	Not available
kcat/kinact	1	Not available	Not available
k2/K (M−1 s−1)	(4.9 ± 0.5) × 104	(5.1 ± 0.1) × 103a	(2.9 ± 0.1) × 103a
koff (s−1)	(3.7 ± 0.4) × 10−4	(3.8 ± 0.2) × 10−5a	(1.9 ± 0.60) × 10−3a
Kd (nM)b	7.5 ±0.7	7a	660a

^aData from reference 6.

^bK_d, dissociation constant.