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EC50 values for NRTIs in parental THP-1 cells versus THP-1KD-SAMHD1 cells
| Drug | EC50 (nM) fora: |
Fold increase in EC50 | |
|---|---|---|---|
| Parental THP-1 cells | THP-1KD-SAMHD1 cells | ||
| AZT | 1.1 ± 0.5 | 25.3 ± 14.9 | 23 |
| TDF | 0.08 ± 0.01 | 1.44 ± 0.04 | 18 |
| d4T | 47 ± 10 | 166 ± 13 | 3.5 |
| ddI | 44 ± 8 | 42 ± 7 | 1 |
| 3TC | 11 ± 2 | 11 ± 4 | 1 |
| EFdA | 0.04 ± 0.02 | 0.13 ± 0.02 | 3.3 |
Values are the mean ± standard deviation (SD) from four independent experiments and were determined using the one-site competition equation in GraphPad Prism 5.
