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Targeted peak concentrations versus concentrations administered in G. mellonella models
| Antimicrobial (human dose) | Targeted free peak concn (mg/liter) | Concn (mg/liter) administered in G. mellonella model |
|---|---|---|
| Daptomycin (6 mg/kg) | 9.8 | 9.15 |
| Daptomycin (10 mg/kg) | 14.0 | 13.07 |
| Linezolid (600 mg) | 14.0 | 8.00a |
| Gentamicin (1.3 mg/kg) | 6.0 | 5.60 |
| Rifampin (300 mg) | 2.6 | 2.50 |
Linezolid concentrations were lower than targeted due to limits on the available pharmaceutical concentrations.
