TABLE 4.

Change in bacterial density from that of the starting inoculum in the SEV model at 8, 24, and 72 h

Antimicrobial regimen	Mean change in bacterial density (log10 CFU/g) from that of the starting inoculuma
	E. faecalis			E. faecium
	8 h	24 h	72 h	8 h	24 h	72 h
Growth control	+1.13	+1.06	+1.29	+1.82	+1.93	+1.86
Daptomycin, 6 mg/kg	−2.07b	−4.28b	−5.07b	−2.11b	−4.56b	−5.86b
Daptomycin, 6 mg/kg, + rifampin	−1.88b	−2.99b	−5.13b	−1.84b	−3.33b	−5.30b
Daptomycin, 6 mg/kg, + gentamicin	−4.36b	−6.02b	−6.15b	−2.38b	−4.96b	−5.05b
Daptomycin, 10 mg/kg	−2.23b	−4.17b	−6.07b	−3.57b	−4.90b	−5.63b
Daptomycin, 10 mg/kg, + rifampin	−1.65b	−3.48b	−5.46b	−2.09b	−3.71b	−5.41b
Daptomycin, 10 mg/kg, + gentamicin	−2.32b	−6.07b	−5.67b	−2.99b	−4.08b	−5.04b
Linezolid	+0.02	−0.19	−0.95	+0.07	−1.08b	−2.90b
Linezolid + rifampin	−0.07	−0.40	−1.96b	+0.45	+0.48	−0.79
Linezolid + gentamicin	+0.13	−0.15	−0.88b	−0.14	−0.67b	−4.08b

^aThe starting inoculum was 5 × 10⁹ CFU/g. Positive values indicate growth.

^bStatistically significantly different from the result with the growth control.