FIG 5.

Effects of LL-37, P60.4Ac, and P10 on MRSA and mupirocin-resistant MRSA-infected thermally wounded HSEs. Thermally wounded HSEs were inoculated with LUH14616 (A) or LUH15051 (B) and after 1 h were subsequently exposed to 100 μg of the various peptides or mupirocin per model. After 24 h, the number of viable bacteria was determined microbiologically. (C) IL-8 in the culture supernatants of the HSEs wounded and infected with LUH14616 after 24 h of exposure to the peptides. ○, LL-37; gray circles, P60.4Ac; ●, P10. Horizontal lines represent the median CFU counts. *, CFU/HSE significantly less than in colonized thermally wounded HSEs without antimicrobial agent (◼).