FIG 9.
Postinfection protective activity of anti-PcrV MAbs V2L2MD and MAb166.2a in the acute murine pneumonia model. BALB/c mice (n = 10) were administered i.v. with V2L2MD, MAb166.2a, or control IgG at the indicated concentrations 1 h after i.n. infection with ∼2× the LD100 dose (1e6 CFU/mouse) of P. aeruginosa cytotoxic exoU strain 6077. The animals were monitored for survival up to 96 h. The results are represented as Kaplan-Meier survival curves; differences in survival were calculated by the log rank test for V2L2MD versus MAb166.2: P = 0.0067, 15 mg/kg; P = 0.0003, 5 mg/kg; and P < 0.0001, 1 mg/kg.