TABLE 7.
Characteristics of 7 patients infected with echinocandin-resistant Candida isolates
| Date of candidemia (day/mo/yr) | Candida species | Underlying condition(s) | Previous antifungals | Resistance | MIC (μg/ml) |
Antifungal treatment | Outcome | |
|---|---|---|---|---|---|---|---|---|
| AND | MYC | |||||||
| 01/01/2007 | C. albicans | Cardiac surgery | No | MYC, AND | 2 | 1 | FLU | Death at 30 days |
| 02/01/2007 | C. krusei | Diabetes, lithiasis | No | MYC, AND, FLU | 0.25 | 0.5 | AmB | Favorable |
| 02/05/2008 | C. tropicalis | Hypopharyngeal cancer | Azoles (FLU) | MYC, AND | 0.125 | 0.125 | CAS, FLU | Death at 30 days |
| 23/08/2010 | C. albicans | Diabetes, lithiasis | Azoles (VRC) | FLU, VRC, POS, MYC | 0.015 | 0.031 | MYC | Favorable |
| 31/10/2011a | C. tropicalis | Renal transplantation | Candins (MYC) | MYC | 0.062 | 0.25 | AmB | Death at 7 days |
| 19/08/2012 | C. albicans | Lymphoepithelioma | No | MYC | 0.015 | 0.031 | AND | Death at 7 days |
| 25/11/2012 | C. albicans | Hemangioblastoma | AmB and azoles (FLU) | MYC | 0.015 | 0.031 | AmB, FLU | Favorable |
a
Patient infected by a C. tropicalis strain harboring a point mutation (R647G) in the HS1 region of the fks1 gene.