TABLE 2.

Antibiotic susceptibility of clpX, clpP, and clpC mutants in different S. aureus strain backgrounds

Antibiotic	MIC (mg/liter) for indicated S. aureus strain or variant:
	8325-4				SA564			JE2				COL
	WTa	ΔclpX	ΔclpP	ΔclpC	WT	ΔclpX	ΔclpP	WT	ΔclpX	clpP::ΦNΣ	clpC::ΦNΣ	WT	ΔclpX	ΔclpP
Oxacillin	0.19–0.25	0.38–0.5	1	0.25	0.38–0.5	1.5–4	0.75	32–48	192–256	>256	48	256	256	256
Ertapenem	0.19	0.19	0.19	0.125	0.19	0.25	0.19	0.5–0.75	2–3	16–24	0.5–0.75	>32	>32	>32
Imipenem	0.047	0.047	0.047	0.064	0.064	0.064	0.094	0.125	0.5–0.75	3–4	0.13–0.19	32	16	16
Cefoxitin	3	3	3	3	4	4	4	24	32–256	>256	24–32	256	256	256
Cefuroxime	1.5	1.5	1.5	1.5	3	3	1.5	24	>256	>256	24–32	2,048	2,048	2,048
Ceftaroline	0.25	0.25	0.25	0.25	0.25	0.25	0.5	0.5	1	1	0.5	2	2	2
Ceftobiprole	0.25	0.5	0.5	0.5	0.5	0.5	0.5	1	2	2	1	2	2	2
Linezolid	2	2	<1	2	4	4	2	2	2	2	2	2	2	2
Vancomycin	1.5	1.5	1.5	1.5	1.5	1	1.5	1	1.5	1.5	1.5	1.5	3	1.5
Daptomycin	0.38–0.75	0.75–1	0.38–0.5	0.38	0.125–0.25	0.38	0.25–0.38	0.19–0.38	0.38	0.5–0.75	0.25	1	1.5	1

^aWT, wild type.