TABLE 3.
Population PK parameters obtained from the PK model for plasma and tissue concentrations of penicillin for swine
| Parameter | Description | Value (RSE [%])a |
Bootstrap value | CI |
||
|---|---|---|---|---|---|---|
| Population mean | IIV | 2.5% | 97.5% | |||
| V1 (liter) | Volume of distribution for the central compartment | 3.05 (8.8) | 0.13 (15) | 3.01 | 2.76 | 3.26 |
| V2 (liter) | Volume of distribution for the peripheral compartment 1 | 1.65 (12) | 0.03 (10) | 1.66 | 1.58 | 1.75 |
| V3 (liter) | Volume of distribution for the peripheral compartment 2 | 4.65 (17) | NE (NA) | 4.61 | 4.51 | 4.70 |
| VK (liter) | Volume of distribution for the kidney compartment | 4.38 (14) | 0.02 (15) | 4.38 | 4.15 | 4.57 |
| VM (liter) | Volume of distribution for the muscle compartment | 1.10 (12) | 0.03 (17) | 0.99 | 0.93 | 1.04 |
| CL1 (liters/h) | Central clearance | 16.9 (14) | 0.12 (14) | 17.2 | 15.8 | 18.8 |
| CL2 (liters/h) | Clearance between the central and the peripheral compartment 1 | 13.7 (85) | NE (NA) | 13.9 | 12.7 | 14.8 |
| CL3 (liters/h) | Clearance between the central and the peripheral compartment 2 | 0.52 (40) | NE (NA) | 0.54 | 0.52 | 0.55 |
| CLK (liters/h) | Clearance between the central and the kidney compartment | 12.1 (53) | 0.06 (15) | 12.2 | 11.4 | 13.1 |
| CLM (liters/h) | Clearance between the central and the muscle compartment | 14.8 (64) | 0.06 (13) | 14.9 | 14.0 | 15.8 |
| Kim1 (liters/h) | Absorption rate constant after i.m. injection of penicillin potassium | 3.03 (27) | 0.04 (15) | 3.00 | 2.84 | 3.18 |
| Kim2 (liters/h) | Absorption rate constant after i.m. injection of procaine penicillin | 0.48 (23) | 0.13 (15) | 0.48 | 0.44 | 0.54 |
| Fim1 (%) | Bioavailability of penicillin after i.m. injection of penicillin potassium | 73.3 (17) | 0.02 (10) | 71.1 | 68.2 | 73.6 |
| Fim2 (%) | Bioavailability of penicillin after i.m. injection of procaine penicillin | 64.2 (15) | 0.14 (14) | 65.1 | 58.5 | 73.3 |
| Covariate factor | ||||||
| θ1 | Estimated covariate factor of wt on V2 | 0.132 | 0.133 | 0.131 | 0.135 | |
| Residual errors (%) | 35 | |||||
a
RSE, relative standard error; NE, not estimated; NA, not applicable.