TABLE 1.
Posaconazole dosage and plasma concentration
| Patient no. | Time from initiation of treatment to death (days) | Dose (mg)a | Results of plasma concn determination closest to death |
Interval between last dose and death (h) | ||||
|---|---|---|---|---|---|---|---|---|
| Time between dose and sampling (h) | Steady state reached | Concn (ng/ml) | Time from sampling to death (days) | Administered dosage (mg) (no. of doses) between sampling and death | ||||
| 1 | 5 | 200 (2 doses 5 days before death, 1 dose 3 days before death) | 21 | No | 30 | 2 | None | 81 |
| 2 | 4 | 400 (2 doses 4 days before death), 200 (2 doses 1 day before death) | 57 | No | 10 | 1 | 200 (2) | 16 |
| 3 | 31 | 200 (q12h, every second day) | 33 | Yes | 40 | 0 | None | 65 |
| 4 | 42 | 200 (q12h, every second day) | 9 | Yes | 70 | 0 | None | 24 |
| 5 | 196 | 200 (q12h, every second day) | 34 | Yes | 50 | 4 | 200 (2) | 79 |
| 6 | 19 | 200 (q12h, every second day) | 33 | Yes | 330 | 3 | 200 (1) | 58 |
| 7 | 22 | 200 (q8h), 200 (q12h the last 2 days before death) | 15 | Yes | 390 | 0 | None | 19 |
a
q12h, every 12 hours; q8h, every 8 hours.