TABLE 3.
Nonsynonymous SNVs found in the coding regions of strains M715 and M1052a
| Strain and ORF | Gene | SNV | Description |
|---|---|---|---|
| M715 | |||
| YBR018C | GAL7 | GAL7S177F | Galactose-1-phosphate uridyl transferase; galactose catabolism |
| YBR026C | ETR1 | ETR1E82G | 2-Enoyl thioester reductase; probable role in fatty acid synthesis |
| YBR120C | CBP6 | CBP6P133S | Mitochondrial translational activator of the COB mRNA; phosphorylated |
| YBR295W | PCA1 | PCA1S431L | Cadmium-transporting P-type ATPase; may have a role in copper and iron homeostasis |
| YKR105C | NA | “NA”K333N | NA |
| YDL194W | SNF3 | SNF3S97F | Plasma membrane low-glucose sensor that regulates glucose transport |
| YDR050C | TPI1 | TPI1N245D | Triose phosphate isomerase |
| YGR047C | TFC4 | TFC4L273F | Subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC) |
| YGR083C | GCD2 | GCD2S2R | Delta subunit of the translation initiation factor eIF2B |
| YHL038C | CBP2 | CBP2M385T | Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA |
| YKL148C | SDH1 | SDH1S121F | Flavoprotein subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain |
| YKL087C | CYT2 | CYT2*54Y | Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome c reductase |
| YLL051C | FRE6 | FRE6S421F | Putative ferric reductase with similarity to Fre2p |
| YMR076C | PDS5 | PDS5S289F | Protein required for establishment and maintenance of sister chromatid condensation and cohesion |
| YOR009W | TIR4 | TIR4S178P | Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins |
| YPL189W | GUP2 | GUP2*133K | Probable membrane protein with a possible role in proton symport of glycerol |
| M1052 | |||
| YAL016W | TPD3 | TPD3S138F | Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A) |
| YBL018C | POP8 | POP8H65Y | Subunit of both RNase MRP |
| YCR020C | PET18 | PET18A150V | Protein of unknown function |
| YDR472W | TRS31 | TRS31Q220H | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion |
| YDR495C | VPS3 | VPS3S521L | Component of CORVET complex |
| YDR505C | PSP1 | PSP1W761* | Asn- and Gln-rich protein of unknown function |
| YER176W | ECM32 | ECM32E530K | DNA-dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination |
| YHL009W-B | NA | “NA”G539S | Retrotransposon TYA Gag and TYB Pol genes |
| YLR181C | VTA1 | VTA1S196I | Multivesicular body (MVB) protein involved in endosomal protein sorting |
| YML080W | DUS1 | DUS1S364L | Dihydrouridine synthase |
| YOR019W | NA | “NA” S693L | Protein of unknown function that may interact with ribosomes |
| YOR191W | ULS1 | ULS1K341N | RING finger protein involved in proteolytic control of sumoylated substrates |
| YPL009C | NA | “NA”E744K | Protein of unknown function |
a
ORF, open reading frame; TCA, tricarboxylic acid; CORVET, class C core vacuole/endosome tethering.