TABLE 1.
Clinical feature | Patient 1 | Patient 2 | Patient 3 |
---|---|---|---|
Age (yr) | 56 | 43 | 58 |
Gender | Male | Male | Male |
Reason for hospital admission | Acute upper gastrointestinal bleeding, high fever | Fracture dislocation caused by a falling | Clonic spasm, high fever, meningitis |
Underlying disease | Hypertension, coronary heart disease, diabetes | Aspiration pneumonia | Hypertension |
Total no. of blood cultures taken | 1 | 9 | 4 |
Date(s) (day/mo/yr) of C. quercitrusa isolationa | 23/05/2010 (7) | 06/06/2010 (50), 28/05/2010 (59) | 29/06/2010 (10) |
Clinical status at time of positive culture | |||
Immunosuppressive state | No | No | No |
Neutropenia (<109 per liter) | No | No | No |
Presence of CVC | No | Yes | Yes |
Broad-spectrum antibiotics | Yes | Yes | Yes |
Total parenteral nutrition | No | Yes | Yes |
Surgery within 30 days | No | Yes | No |
Intensive care | Yes | Yes | Yes |
Previous antifungal agents within 30 days | No | Yes | No |
Concomitant bacteremia | No | No | No |
Concomitant candidemia | No | Yes (Candida lipolytica) | No |
Indwelling urinary catheter | No | Yes | Yes |
Therapy | |||
Antifungal | No antifungal therapy commenced | Voriconazole 400 mg daily, 14 days | Caspofungin 50 mg daily, 8 days |
CVC removala | Not applicable | Yes (64) | Yes (10) |
Antifungal, after culture | Yes | Yes | Yes |
Outcome | Unknownb | Recovered | Recovered |
Numbers in parentheses indicate days since beginning of hospitalization.
Patient discharged against medical advice and was lost to further follow-up.