TABLE 2.
Bacterial taxa that demonstrated the largest changes in relative abundance at the onset of exacerbation compared to that at the most recent preexacerbation time point (Pre2)a
| Taxon (class/family/genus) | prokMSA_ID for taxon representative speciesb | Fold changec | P value |
|---|---|---|---|
| Gammaproteobacteria/Moraxellaceae/Acinetobacter | 60270 | +2.9 | 0.01 |
| Gammaproteobacteria/Moraxellaceae/Perlucidibaca | 105696 | +2.7 | 0.02 |
| Gammaproteobacteria/Moraxellaceae/Acinetobacter | 106871 | +2.4 | 0.04 |
| Gammaproteobacteria/Moraxellaceae/Acinetobacter | 101304 | +2.4 | 0.006 |
| Betaproteobacteria/Anaplasmataceae/Ehrlichia | 6030 | +2.2 | 0.02 |
| Gammaproteobacteria/Pasteurellaceae/Actinobacillus | 52835 | +2.1 | 0.04 |
| Alphaproteobacteria/Sphingomonadaceae/Sphingomonas | 89065 | +2.1 | 0.01 |
| Betaproteobacteria/Comamonadaceae/Comamonas | 71872 | +2.0 | 0.03 |
| Gammaproteobacteria/Enterobacteriaceae | 10365 | +2.0 | 0.04 |
| Gammaproteobacteria/Pseudomonadaceae/Pseudomonas | 8434 | +2.0 | 0.01 |
| Bacilli/Bacillaceae/unclassified | 89195 | −1.9 | 0.04 |
| Epsilonproteobacteria/Campylobacteraceae/Campylobacter | 108770 | −1.9 | 0.03 |
| Bacteroidia/Rikenellaceae/unclassified | 101395 | −1.9 | 0.01 |
| Clostridia/Clostridiales family XIII/Mogibacterium | 14167 | −1.8 | 0.002 |
| Actinobacteria/Microbacteriaceae/Agromyces | 12174 | −1.8 | 0.02 |
| Clostridia/Lachnospiraceae/unclassified | 72977 | −1.8 | 0.005 |
| Actinobacteria/ACK-M1/unclassified | 96076 | −1.8 | 0.01 |
| Actinobacteria/Micrococcaceae/Rothia | 58305 | −1.8 | 0.03 |
| Actinobacteria/Nocardiaceae/Rhodococcus | 85556 | −1.8 | 0.04 |
a
Changes in relative abundance were ≥2-fold (P < 0.05, q ≤ 0.30) at the onset of exacerbation compared to that at the most recent preexacerbation time point (Pre2). The results are based on analysis of all subjects in the study (n = 12 subjects).
b
prokMSA_ID is the identifier used by the Greengenes database.
c
Fold change shows the increase or decrease at exacerbation.