TABLE 4.
The relationships of quartiles of viral load, as measured by CT values from cobas, for HPV16, HPV18, and other carcinogenic HPV types with histologically confirmed AIN2 or AIN3 among HPV-positive mena
| Quartile of viral load | HPV16 |
HPV18 |
Other carcinogenic type |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <AIN2b | AIN2/3b | Totalb | ORc | 95% CId | <AIN2b | AIN2/3b | Totalb | OR | 95% CI | <AIN2b | AIN2/3b | Totalb | OR | 95% CI | |
| 4th | 13 (45) | 16 (55) | 29 (100) | 11 | 2.3–64 | 7 (64) | 4 (36) | 11 (100) | 5.7 | 0.41–310 | 44 (66) | 23 (34) | 67 (100) | 35 | 5.2–1400 |
| 3rd | 23 (79) | 6 (21) | 29 (100) | 2.3 | 0.42–15 | 8 (67) | 4 (33) | 12 (100) | 5.0 | 0.36–270 | 60 (83) | 12 (17) | 72 (100) | 13 | 1.9–580 |
| 2nd | 25 (83) | 5 (17) | 30 (100) | 1.7 | 0.3–13 | 10 (91) | 1 (9) | 11 (100) | 1.0 | 0.012–86 | 62 (89) | 8 (11) | 70 (100) | 8.6 | 1.1–390 |
| 1st | 26 (90) | 3 (10) | 29 (100) | 1.0 | Ref | 10 (91) | 1 (9) | 11 (100) | 1.0 | Ref | 67 (99) | 1 (1) | 68 (100) | 1.0 | Ref |
| Ptrende | <0.001 | 0.07 | <0.001 | ||||||||||||
a
Logistic regression was used to calculate the odds ratio and 95% confidence interval as measures of association of the higher viral load (versus 1st quartile) with anal intraepithelial neoplasia grade 2/3 (AIN2/3).
b
Values shown are no. (row %).
c
OR, odds ratio.
d
CI, confidence interval; Ref, reference category.
e
As a test of trend, quartiles of viral load were also treated as continuous variables in the logistic regression model.