FIG 6.

Cytokine profiles are altered in the serum from mice with persistent infections. Serum from infected FVB/N mice was sampled and analyzed by multiplex array for IL-4, IL-1β, IL-17, TNF-α, and KC on day 1 (n = 5), day 3 (n = 5), day 7 (n = 6), day 21 (n = 8), day 29 (n = 5), day 36 (n = 10 persistent), and day 42 (n = 7 persistent). Levels of KC in sera from infected mice are compared with levels in samples from mice that cleared infection on days 13 to 29 (day 36, n = 9; day 42, n = 5). The levels of analyzed cytokines in control serum were unchanged through the infection period and therefore were combined. Controls (n = 2) from each time point were grouped together. Data are presented as means ± standard errors of the means. Differences between controls and the respective analysis day were analyzed by unpaired t tests, with significance set at P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***).