TABLE 5.
Infectivity of B. burgdorferi dbpA lysine point mutants in C3H/HeN mice during early infection
| Strain | No. of positive cultures/total |
No. of positive mice/total | ||||
|---|---|---|---|---|---|---|
| Ear punch | Lymph nodesa | Heart | Tibiotarsal | All sites | ||
| BbKH500b | 0/5 | 0/5 | 0/5 | 0/5 | 0/20 | 0/5 |
| BbKH501 | 5/5 | 5/5 | 5/5 | 4/5 | 19/20 | 5/5 |
| BbDbpAK51A | 5/5 | 5/5 | 5/5 | 4/5 | 19/20 | 5/5 |
| BbDbpAK82Ab | 0/5 | 0/5 | 0/5 | 0/5 | 0/20 | 0/5 |
| BbDbpAK124A | 5/5 | 5/5 | 5/5 | 4/5 | 19/20 | 5/5 |
| BbDbpAK163Ab | 0/5 | 0/5 | 0/5 | 0/5 | 0/20 | 0/5 |
| BbDbpAK170Ab | 0/5 | 0/5 | 0/5 | 0/5 | 0/20 | 0/5 |
| BbDbpAK177A | 5/5 | 4/5 | 4/5 | 4/5 | 17/20 | 5/5 |
a
A single brachial and inguinal lymph node were collected from each mouse and cultured together.
b
The reduction in infection rates observed in individual tissues, at all sites, and the overall number of positive mice were statistically significantly different from BbKH501 (P ≤ 0.05 based on Fisher's exact test).