FIG 2.

pLL potentiates the production of IL-10 and inhibits that of IL-12/23p40 and IL-12p70 in BMDCs stimulated with TLR agonists. BMDCs were incubated with the doses of FD-pLL indicated (μg) and stimulated with either LPS or Pam3CSK, and cytokine levels in the supernatants were measured. The error bars indicate the standard deviations (SD) of triplicate wells. ANOVA gave overall P values of <0.0001 for all the stimulus-response combinations shown. The results shown are representative of at least 6 (LPS) or 3 (Pam3CSK) independent experiments. The asterisks denote differences with respect to stimulation with TLR agonist alone. ***, P < 0.001; *, P < 0.05.