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Extensive sequence analysis of M. tuberculosis clinical isolates reveals that whiB6 mutation is exclusive of H37Rv and independent of the M. tuberculosis lineage. The whiB6 promoter region of 76 clinical isolates from our laboratory collection was sequenced. The dendrogram based on spoligotyping of the clinical isolates reveals that the G insertion in H37Rv is independent of the lineage. Spoligotyping is further detailed in Fig. S1 in the supplemental material.
