FIG 4.
Effect of C5 deficiency on live organism recovery from mouse genital tracts following C. muridarum infection. Mice without (C5+/+; n = 5 for each time point) or with (C5−/−; n = 5 for each time point) deficiency in C5 were infected intravaginally with C. muridarum. Seven (a), 10 (b), or 14 (c) days after infection, mouse genital tract tissues were harvested and separated into vagina/cervix (VC) (representing the LGT) and uterine/uterine horn (UH) and oviduct/ovary (OV) (representing the UGT) segments. These segments were homogenized to measure live chlamydial organisms expressed as log10 IFU. Note that similar numbers of live organisms were recovered from both C5+/+ and C5−/− mice in all tissue segments and at all time points. The error bars indicate standard deviations.