FIG 1.

Clearance of malaria parasites from the blood of infected mice by use of ART, as well as analyses of liver function before parasite clearance and with time after parasite clearance. (A) Percentages of parasitemia in infected mice before and after ART treatment. Restoration of liver function was studied just before and after parasite clearance (day 1 to day 25 post-parasite clearance). Liver function tests were based on measurements of the activities of alkaline phosphatase (ALP) (B), alanine transaminase (ALT) (C), and aspartate transaminase (AST) (D), along with measurements of total bilirubin (E), unconjugated bilirubin (F), conjugated bilirubin (G), and albumin (H), in the sera of noninfected mice, infected mice, noninfected + ART mice, and infected + ART mice on day 1, day 3, day 5, day 10, day 15, and day 25 after clearance of parasites from the blood. The details of the methodology are described in Materials and Methods. Data are presented as means ± SEM. *, P < 0.05 versus noninfected mice (n = 6).