FIG 4.

Activity and expression of HO-1 in the liver during malaria and after parasite clearance. (A) Activities of HO-1 in the livers of noninfected, infected, noninfected + ART, and infected + ART mice on day 1, day 3, day 5, day 10, day 15, and day 25 after clearance of parasites from the blood. (B) Western immunoblot of HO-1 in the livers of noninfected, noninfected + ART, and infected + ART mice on day 1, day 3, day 5, day 10, day 15, and day 25 after clearance of parasites from the blood. (C) Densitometric analyses of Western immunoblots to quantitate HO-1 expression. Data are given as fold changes relative to the levels in the noninfected group. The details of the methodology are described in Materials and Methods. Data are presented as means ± SEM. *, P < 0.05 versus noninfected mice (n = 6).