TABLE 1.
Inhibitors used in this studya
| Inhibitor | Target | Concn (μM) | LVS growthb |
|---|---|---|---|
| MJ33 | iPLA2 | 10 | ↔ |
| Pyrrophenone | cPLA2 | 5 | ↔ |
| CAY10590 | sPLA2 | 20 | ↔ |
| D609 | PC-PLC | 30 | ↓ |
| Edelfosine | PI-PLC | 30 | ↔ |
| Propranolol | PAP | 100 | ↑ |
| RHC80267 | DAGL | 25 | ↔ |
| JZL184 | MAGL | 0.3 | ↔ |
| VU0155056 | PLD1/2 | 10 | ↔ |
| Bromoenol lactone | iPLA2 | 1 | ↓ |
| U73122 | PLC | 5 | ↔ |
a
The inhibitors used in the study are listed with their target, concentration, and effect on F. tularensis LVS growth in broth. Inhibitors that decreased LVS growth in broth were removed from the study.
b
Symbols: ↔, no change in bacterial growth; ↓, decreased bacterial growth; ↑, increased bacterial growth.